Tesofensine: uses, dosing & the facts

A triple monoamine reuptake inhibitor that blocks serotonin, norepinephrine, and dopamine reuptake. Originally developed for Alzheimer's and Parkinson's, now researched for significant weight loss effects. This is an evidence-graded reference — what it is, what it's used for, typical reported dosing, half-life, side effects, and how to track it. It is educational, not medical advice or a recommendation to use a research compound.

By OptiPin Editorial·Last updated July 2026

Status

Research use only · not FDA-approved. Reported dosing below reflects community-discussed patterns, presented for information only — not a dose recommendation. For the US regulatory picture on research peptides, see the 2026 FDA compounding status.

Class

Fat loss

Used for

Weight loss and appetite suppression

Half-life

Approximately 2-3 days

Status

Research use only

TL;DR

• Tesofensine — Fat loss. A triple monoamine reuptake inhibitor that blocks serotonin, norepinephrine, and dopamine reuptake.
• Commonly used for weight loss and appetite suppression, increased energy expenditure, metabolic enhancement.
• Half-life: Approximately 2-3 days.
• Status: Research use only · not FDA-approved — an educational reference, not a dose protocol or sourcing advice.

What Tesofensine is

What Tesofensine is used for

• Weight loss and appetite suppression
• Increased energy expenditure
• Metabolic enhancement
• Obese and overweight treatment
• Improved body composition

These are reported/community uses, not proven clinical outcomes. Most research peptides have limited human trial data behind such claims.

Typical reported dosing

Oral	Starting dose: 250mcg daily for weight loss. Most studied dose: 500mcg daily (yielding up to 10% body weight loss over 6 months). Higher dose: 1000mcg daily (used cautiously due to increased side effects)

Presented as commonly-reported patterns for information only — not a dose recommendation. Tesofensine dosing is a decision for a qualified clinician.

Half-life & cycling

Half-life: Approximately 2-3 days. Half-life drives dosing frequency and how quickly the compound clears — see it plotted on the half-life visualizer.

Cycling

Can be used for extended periods with medical supervision. Typical treatment duration: 6-12 months. Gradual dose escalation recommended.

Side effects & warnings

• Increased heart rate
• Elevated blood pressure
• Insomnia
• Dry mouth
• Constipation
• Headache
• Jitteriness at higher doses

Can significantly increase heart rate and blood pressure. Monitor cardiovascular health closely. Not suitable for those with cardiovascular conditions. Start with lower doses (250mcg). 1000mcg doses significantly increase side effects.

Not a prescription, a dose, or a sourcing guide. Tesofensine is a research compound; safety and efficacy in humans are not fully established, and research-grade material has no guarantee of purity, sterility, or stated strength. OptiPin is a tracking tool and does not recommend using research chemicals. Discuss any peptide with a qualified clinician.

Tracking Tesofensine in OptiPin

If you're tracking a Tesofensine protocol, OptiPin logs each dose with reminders and site rotation, charts the outcome you care about over your dose timeline, keeps per-vial inventory with runout warnings, and (where relevant) does the reconstitution math — all on-device, no account.

Track it properly

Log doses, outcomes & vials in OptiPin

Reminders, outcome-over-dose charts, vial runout warnings, and built-in reconstitution math — all on-device.

Download on the App Store

FAQ

What is Tesofensine?

What is Tesofensine used for?

Commonly discussed uses include: weight loss and appetite suppression, increased energy expenditure, metabolic enhancement, obese and overweight treatment, improved body composition. These are reported uses, not proven outcomes or a recommendation.

How is Tesofensine dosed?

Commonly reported dosing: Oral — Starting dose: 250mcg daily for weight loss. Most studied dose: 500mcg daily (yielding up to 10% body weight loss over 6 months). Higher dose: 1000mcg daily (used cautiously due to increased side effects). This reflects patterns discussed in the community and is presented for information only, not as a dose recommendation — Tesofensine is not an approved medicine and dosing should involve a qualified clinician.

What is Tesofensine's half-life?

Approximately 2-3 days. Half-life shapes how often it is dosed and how quickly it clears.

What are Tesofensine's side effects?

Reported effects include: increased heart rate, elevated blood pressure, insomnia, dry mouth, constipation, headache, jitteriness at higher doses. Because it is a research compound, its safety profile is not fully characterized; discuss risks with a clinician.

Educational only, not medical advice. Tesofensine is a research compound and is not an approved medicine for the uses described. OptiPin is a tracking tool and does not provide dosing or treatment advice. Discuss any peptide with a qualified clinician.

Evidence & further reading

Search the peer-reviewed literature for Tesofensine on PubMed (entry point to the primary evidence base, not a specific citation).
Tesofensine on ClinicalTrials.gov — registered human trials, if any.
US FDA / 503A compounding status of research peptides (2026).
OptiPin peptides guide — categories, evidence grading, and how to run a protocol honestly.

5-Amino-1MQ · AOD-9604 · BAM-15 · Cagrilintide · Tirzepatide (Mounjaro/Zepbound) · Reconstitution calculator · All peptides