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GLP-1 titration schedule

The standard manufacturer titration for semaglutide and tirzepatide, mapped week-by-week to calendar dates from your start date.

By OptiPin Editorial·Last updated
WeeksDatesWeekly dose

* For tirzepatide, doses are increased in 2.5 mg steps every 4 weeks only as needed and tolerated; many people stabilize below 15 mg. Dates assume each step lasts the full 4 weeks.

Reference only — not medical advice. This reproduces the standard manufacturer (FDA label) titration schedule and maps it to dates. Your prescriber may escalate more slowly, hold a dose for tolerability, or use a different target. Doses, side effects, and timing must be managed with your prescriber. Do not start, change, or stop a medication based on this tool.
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Setting up a full titration schedule — with automatic dose step-ups on the dates you choose — takes seconds in OptiPin. It then logs each dose, reminds you when to escalate, tracks side effects and weight, and forecasts medication levels between doses — all on-device, no cloud required.

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About GLP-1 titration

GLP-1 medications are titrated slowly to reduce gastrointestinal side effects like nausea. The schedules here are the standard label escalations; many clinicians extend a step if side effects are significant. Read more in our GLP-1 guide and side-effects reference.

Need to convert a vial dose to syringe units? Use the peptide/GLP-1 reconstitution calculator.