Steroid stack checker

What this checker is and is not

It is a published list of rules, each tied to a drug label or a study, run against the compounds you pick. When a rule fires you see what it says, which of your compounds set it off, the markers worth testing and the symptoms that mean getting care. The rule count and review date come straight from the rule file.

It is not a safety verdict and it does not give doses, ratios, schedules or protocols. Where a source supports it, a card says how a finding is usually handled (by class with one example) and who decides. The list is finite and covers only what a source supports, so most combinations will return nothing. Nothing flagged means nothing in this list applies, not that the stack is fine. Your dose, your health history and your bloodwork decide that, together with whoever reviews it.

How to read the three tiers

• Interaction. A drug label or a pharmacokinetic study describes the combination itself.
• Organ load. Each compound is known to push the same organ or marker the same way. That the combination adds up is an inference from the class evidence. The card says so.
• Evidence thin. The concern rests on a mechanism, animal data or a gap in human data. It is shown so you know the question exists, not because it is settled.

How we label evidence

Each card carries a label for the evidence behind its main claim and another for the evidence behind how the finding is usually handled. The two can differ: a concern can rest on a mechanism while the way people handle it is documented off-label use.

• Drug label A drug's US prescribing information says it.
• Clinical evidence Guidelines, clinical reviews or studies in people describe it.
• Off-label use People use it outside its label, documented by a survey or review rather than a forum post alone. Always paired with a clinician referral.
• Mechanism Follows from chemistry, receptor or animal data. Not shown in people.
• Anecdotal Community reports only. The card says so.

None of the five ever comes with a dose.

What to do with a result

The bloodwork plan under the results gathers every marker the fired rules name, so you can see one panel for the whole stack instead of one per compound. Take it to your clinician or lab. A baseline before a change and a repeat after it tells you far more than a single number. That is why many of the rules ask for a baseline.

This page follows the same posture as the rest of OptiPin: people run these compounds whether or not anyone approves. Accurate information about what to watch is better than none. That is why it names markers, red flags and how findings are usually handled, labels the evidence for each and stops there.

Common stack pairs

Pairs with a page of their own: what the rules say about the combination, what each compound adds alone and what to monitor.

• Tamoxifen and anastrozole together
• Tamoxifen and letrozole together
• Testosterone and warfarin
• Semaglutide and insulin together
• Tirzepatide and insulin together
• PT-141 and Melanotan II together
• Anavar and Winstrol together
• Testosterone and Deca together
• Testosterone and Masteron together
• Testosterone and trenbolone together
• MK-677 and retatrutide together
• Clenbuterol and T3 together
• Clenbuterol and ephedrine together
• Deca and finasteride together

Frequently asked questions

What does the stack checker look for?

Three things. Interactions that a drug label or a pharmacokinetic study describes for the pair itself. Organ load, where several compounds in the stack each push the same organ or marker the same way. And pairings where the evidence is thin, shown as thin. Each result names the compounds that triggered it, the markers that read it and the sources behind it.

If nothing is flagged, is my stack safe?

No. An empty result means none of the rules in this list fired for the compounds you picked. The list is short on purpose and only holds what a source supports. It does not know your dose, your health history, other medicines and supplements you take or how long you have been running anything. Your bloodwork and your clinician are what tell you how a stack is going.

Why does it not give doses?

Because a list of rules cannot know your situation and a dose suggestion from one would be a guess with a number on it. Where a drug label, clinical evidence or documented off-label use supports it, a card says how a finding is usually handled (by class with one example), labels which of those it is and says it is a clinician's call. It never gives a dose, a dose change or a protocol. What to do about a result is a decision for you and whoever reviews your bloodwork.

What do the three tiers mean?

Interaction means a drug label or a pharmacokinetic study describes the combination. Organ load means each compound is known to affect the same organ or marker. The combined effect is an inference from that. Evidence thin means the concern rests on a mechanism, animal data or the absence of human data. It is labeled that way so it does not read as settled.

What do the evidence labels mean?

Every rule and every "usually handled" line carries one of five labels. Drug label: A drug's US prescribing information says it. Clinical evidence: Guidelines, clinical reviews or studies in people describe it. Off-label use: people use it outside its label, documented by a survey or review rather than a forum post alone. It always comes with a clinician referral. Mechanism: it follows from chemistry, receptor or animal data but has not been shown in people. Anecdotal: community reports only, said as such. None of the five ever comes with a dose.

Where do the rules come from?

Each rule cites US drug labels from DailyMed or published studies on PubMed, with the date each source was checked. The full rule file is public at optipin.app/data/stack-rules.json and the page reads it directly, so what you see is what the file says.

Sources

Every result card lists its own sources with the date each was checked. The full rule file, including every citation, is public at optipin.app/data/stack-rules.json.

Related tools and guides

• Steroid cycle calculator – weekly milligrams and active hormone across a stack.
• Half-life calculator – how long each compound stays on board.
• Liver enzymes on cycle – reading ALT, AST and GGT.
• High hematocrit on TRT and steroids – what the number means and when to act.
• Estradiol in men – what aromatization does and how to test it.
• Prolactin and the 19-nors – why nandrolone and trenbolone change the panel.
• Bloodwork guide – which tests, when and why timing matters.